Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage

Alcoholic liver disease is a significant contributor to global liver failure. In murine models, chronic ethanol consumption dysregulates PTEN/Akt signaling. Hepatospecific deletion of phosphatase and tensin homolog deleted on chromosome 10 (PTEN(LKO)) mice possess constitutive activation of Akt(s) a...

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Udgivet i:PLoS One
Main Authors: Shearn, Colin T., Orlicky, David J., McCullough, Rebecca L., Jiang, Hua, Maclean, Kenneth N., Mercer, Kelly E., Stiles, Bangyan L., Saba, Laura M., Ronis, Martin J., Petersen, Dennis R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849752/
https://ncbi.nlm.nih.gov/pubmed/27124661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154152
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