The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen

Mechanical injury to the skin results in activation of the complement component C3 and release of the anaphylatoxin C3a. C3a binds to a seven-transmembrane G protein–coupled receptor, C3aR. We used C3aR(–/–) mice to examine the role of C3a in a mouse model of allergic inflammation induced by epicuta...

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Bibliografski detalji
Glavni autori: Kawamoto, Seiji, Yalcindag, Ali, Laouini, Dhafer, Brodeur, Scott, Bryce, Paul, Lu, Bao, Humbles, Alison A., Oettgen, Hans, Gerard, Craig, Geha, Raif S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2004
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC484971/
https://ncbi.nlm.nih.gov/pubmed/15286806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419082
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