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The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen
Mechanical injury to the skin results in activation of the complement component C3 and release of the anaphylatoxin C3a. C3a binds to a seven-transmembrane G protein–coupled receptor, C3aR. We used C3aR(–/–) mice to examine the role of C3a in a mouse model of allergic inflammation induced by epicuta...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC484971/ https://ncbi.nlm.nih.gov/pubmed/15286806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419082 |
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