Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

BACKGROUND: Trimetazidine, as an anti-ischemic and antioxidant agent, has been demonstrated to have many cardioprotective effects. However, whether early administration of trimetazidine has an effect on diabetic cardiomyopathy and the mechanisms underlying the effect have not yet been elucidated. ME...

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Опубликовано в: :J Transl Med
Главные авторы: Zhang, Lei, Ding, Wen-yuan, Wang, Zhi-hao, Tang, Meng-xiong, Wang, Feng, Li, Ya, Zhong, Ming, Zhang, Yun, Zhang, Wei
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848862/
https://ncbi.nlm.nih.gov/pubmed/27121077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0849-1
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