Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy

BACKGROUND: Trimetazidine, as an anti-ischemic and antioxidant agent, has been demonstrated to have many cardioprotective effects. However, whether early administration of trimetazidine has an effect on diabetic cardiomyopathy and the mechanisms underlying the effect have not yet been elucidated. ME...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Zhang, Lei, Ding, Wen-yuan, Wang, Zhi-hao, Tang, Meng-xiong, Wang, Feng, Li, Ya, Zhong, Ming, Zhang, Yun, Zhang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848862/
https://ncbi.nlm.nih.gov/pubmed/27121077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0849-1
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