The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

Inhibitor of apoptosis proteins (IAPs) antagonize caspase activation and regulate death receptor signaling cascades. LCL-161 is a small molecule second mitochondrial activator of caspase (SMAC) mimetic, which both disengages IAPs from caspases and induces proteasomal degradation of cIAP-1 and -2, re...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogenesis
Auteurs principaux: West, A C, Martin, B P, Andrews, D A, Hogg, S J, Banerjee, A, Grigoriadis, G, Johnstone, R W, Shortt, J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Short Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848837/
https://ncbi.nlm.nih.gov/pubmed/27043662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.26
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