Identification of Small‐Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia‐1 (Mcl‐1)

Protein–protein interactions (PPIs) control many cellular processes in cancer and tumour growth. Of significant interest is the role PPIs play in regulating apoptosis. The overexpression of the antiapoptosis regulating Bcl‐2 family of proteins is commonly observed in several cancers, leading to resi...

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Bibliographic Details
Published in:ChemMedChem
Main Authors: Beekman, Andrew M., O'Connell, Maria A., Howell, Lesley A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848766/
https://ncbi.nlm.nih.gov/pubmed/26616140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500488
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