ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation

Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional level. Previously, we reported that nSMase2 is...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Clarke, Christopher J., Shamseddine, Achraf A., Jacob, Joseph J., Khalife, Gabrielle, Burns, Tara A., Hannun, Yusuf A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847633/
https://ncbi.nlm.nih.gov/pubmed/27013100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M067447
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