ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Approximately 20 % of familial Amyotrophic Lateral Sclerosis (ALS) is caused by mutations in superoxide dismutase (SOD1), which leads to misfolding of the SOD1 protein, resulting in a toxic gain of function. Several conformation-restricted antibodies have been generated that specifically recognize m...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Pickles, Sarah, Semmler, Sabrina, Broom, Helen R., Destroismaisons, Laurie, Legroux, Laurine, Arbour, Nathalie, Meiering, Elizabeth, Cashman, Neil R., Vande Velde, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847257/
https://ncbi.nlm.nih.gov/pubmed/27121871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0313-8
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