ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Approximately 20 % of familial Amyotrophic Lateral Sclerosis (ALS) is caused by mutations in superoxide dismutase (SOD1), which leads to misfolding of the SOD1 protein, resulting in a toxic gain of function. Several conformation-restricted antibodies have been generated that specifically recognize m...

Full description

Saved in:

Bibliographic Details
Published in:	Acta Neuropathol Commun
Main Authors:	Pickles, Sarah, Semmler, Sabrina, Broom, Helen R., Destroismaisons, Laurie, Legroux, Laurine, Arbour, Nathalie, Meiering, Elizabeth, Cashman, Neil R., Vande Velde, Christine
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2016
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4847257/ https://ncbi.nlm.nih.gov/pubmed/27121871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0313-8
Tags:	Add Tag No Tags, Be the first to tag this record!

ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Similar Items