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Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in understanding ALS disease pathology has been the identification and atomic-level characterization of these conformers. Here, we...
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| 出版年: | eLife |
|---|---|
| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4475725/ https://ncbi.nlm.nih.gov/pubmed/26099300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07296 |
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