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Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, in some cases, has been linked with mutations to the antioxidant metalloenzyme superoxide dismutase (SOD1). Although the mature form of this enzyme is highly stable and resistant to aggregation, the most immature form, lacking...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111666/ https://ncbi.nlm.nih.gov/pubmed/27791136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611418113 |
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