Long-term retention of CENP-A nucleosomes in mammalian oocytes underpins transgenerational inheritance of centromere identity

Centromeres control genetic inheritance by directing chromosome segregation but are not genetically encoded themselves. Rather, centromeres are defined by nucleosomes containing CENP-A, a histone H3 variant [1]. In cycling somatic cells, centromere identity is maintained by an established cell cycle...

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Bibliographic Details
Published in:Curr Biol
Main Authors: Smoak, Evan M., Stein, Paula, Schultz, Richard M., Lampson, Michael A., Black, Ben E.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846481/
https://ncbi.nlm.nih.gov/pubmed/27040782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.02.061
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