Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis

In a previous study we reported the role of potent bisindole-PBD conjugate as an inclusion in the arsenal of breast cancer therapeutics. In breast cancer cell proliferation, PI3K/AKT/mTOR pathway plays a crucial role by prosurvival mechanism that inhibits programmed cell death. Here, 2 breast cancer...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Sarma, Pranjal, Bag, Indira, Ramaiah, M Janaki, Kamal, Ahmed, Bhadra, Utpal, Pal Bhadra, Manika
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846128/
https://ncbi.nlm.nih.gov/pubmed/26192233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1071731
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