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A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway
DNA damage response (DDR) that includes cell cycle check points, DNA repair, apoptosis, and senescence is intimately linked with cancer. It shields an organism against cancer development when genomic integrity fails. DNA repair pathways protect the cells from tumor progression caused as a result of...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Landes Bioscience
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4130725/ https://ncbi.nlm.nih.gov/pubmed/25010292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29705 |
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