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A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway

DNA damage response (DDR) that includes cell cycle check points, DNA repair, apoptosis, and senescence is intimately linked with cancer. It shields an organism against cancer development when genomic integrity fails. DNA repair pathways protect the cells from tumor progression caused as a result of...

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Detalhes bibliográficos
Main Authors: Sarma, Pranjal, Ramaiah, M Janaki, Kamal, Ahmed, Bhadra, Utpal, Bhadra, Manika Pal
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130725/
https://ncbi.nlm.nih.gov/pubmed/25010292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29705
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