Plk1 inhibition enhances the efficacy of gemcitabine in human pancreatic cancer

Gemcitabine is the standard-of-care for chemotherapy in patients with pancreatic adenocarcinoma and it can directly incorporate into DNA or inhibit ribonucleotide reductase to prevent DNA replication and, thus, tumor cell growth. Most pancreatic tumors, however, develop resistance to gemcitabine. Po...

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Publicado en:Cell Cycle
Main Authors: Li, Jie, Wang, Ruixin, Schweickert, Patrick G., Karki, Anju, Yang, Yi, Kong, Yifan, Ahmad, Nihal, Konieczny, Stephen F., Liu, Xiaoqi
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845940/
https://ncbi.nlm.nih.gov/pubmed/26890815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1148838
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