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Plk1 inhibition enhances the efficacy of BET epigenetic reader blockade in castration-resistant prostate cancer

Polo-like kinase 1 (Plk1), a crucial regulator of cell cycle progression, is overexpressed in multiple types of cancers, and has been proven to be a potent and promising target for cancer treatment. In case of prostate cancer, we once showed that anti-neoplastic activity of Plk1 inhibitor is largely...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cancer Ther
Prif Awduron: Mao, Fengyi, Li, Jie, Luo, Qian, Wang, Ruixin, Kong, Yifan, Carlock, Colin, Liu, Zian, Elzey, Bennet D., Liu, Xiaoqi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030429/
https://ncbi.nlm.nih.gov/pubmed/29716963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0945
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