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The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors
RAF- and MEK-targeted therapies are approved for patients with BRAF(V600E) melanoma and under investigation in a several other tumor types, but resistance remains a major challenge. We uncovered yes-associated protein 1 (YAP1) as a mechanism of resistance to RAF-MEK inhibition in BRAF- and RAS-mutan...
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| Udgivet i: | Mol Cell Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845171/ https://ncbi.nlm.nih.gov/pubmed/27308535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1021441 |
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