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The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors
RAF- and MEK-targeted therapies are approved for patients with BRAF(V600E) melanoma and under investigation in a several other tumor types, but resistance remains a major challenge. We uncovered yes-associated protein 1 (YAP1) as a mechanism of resistance to RAF-MEK inhibition in BRAF- and RAS-mutan...
में बचाया:
| में प्रकाशित: | Mol Cell Oncol |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Taylor & Francis
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845171/ https://ncbi.nlm.nih.gov/pubmed/27308535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1021441 |
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