Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Cellular senescence, a stress-induced irreversible growth arrest often characterized by p16(Ink4a) expression and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing. Senescent cell...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Baker, Darren J., Childs, Bennett G., Durik, Matej, Wijers, Melinde E., Sieben, Cynthia J., Zhong, Jian, Saltness, Rachel, Jeganathan, Karthik B., Versoza, Grace C., Pezeshki, Abdul-Mohammad, Khazaie, Khashayarsha, Miller, Jordan D., van Deursen, Jan M.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845101/
https://ncbi.nlm.nih.gov/pubmed/26840489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16932
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