Transcription Errors Induce Proteotoxic Stress and Shorten Cellular Lifespan

Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitored yeast cells that were genetically engineered to display error-prone transcription. We discovered that these cells suffer from a profound loss in prote...

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I publikationen:Nat Commun
Huvudupphovsmän: Vermulst, Marc, Denney, Ashley S., Lang, Michael J., Hung, Chao-Wei, Moore, Stephanie, Mosely, M. Arthur, Thompson, J. Will, Madden, Victoria, Gauer, Jacob, Wolfe, Katie J., Summers, Daniel W., Schleit, Jennifer, Sutphin, George L., Haroon, Suraiya, Holczbauer, Agnes, Caine, Joanne, Jorgenson, James, Cyr, Douglas, Kaeberlein, Matt, Strathern, Jeffrey N., Duncan, Mara C., Erie, Dorothy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684168/
https://ncbi.nlm.nih.gov/pubmed/26304740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9065
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