Selective inhibition of the kinase DYRK1A by targeting its folding process

Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase a...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kii, Isao, Sumida, Yuto, Goto, Toshiyasu, Sonamoto, Rie, Okuno, Yukiko, Yoshida, Suguru, Kato-Sumida, Tomoe, Koike, Yuka, Abe, Minako, Nonaka, Yosuke, Ikura, Teikichi, Ito, Nobutoshi, Shibuya, Hiroshi, Hosoya, Takamitsu, Hagiwara, Masatoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844702/
https://ncbi.nlm.nih.gov/pubmed/27102360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11391
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