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DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain
Two missense mutations of the DYRK1B gene have recently been found to co-segregate with a rare autosomal-dominant form of metabolic syndrome. This gene encodes a member of the DYRK family of protein kinases, which depend on tyrosine autophosphorylation to acquire the catalytically active conformatio...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526990/ https://ncbi.nlm.nih.gov/pubmed/28743892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06874-w |
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