DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

Two missense mutations of the DYRK1B gene have recently been found to co-segregate with a rare autosomal-dominant form of metabolic syndrome. This gene encodes a member of the DYRK family of protein kinases, which depend on tyrosine autophosphorylation to acquire the catalytically active conformatio...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Abu Jhaisha, Samira, Widowati, Esti W., Kii, Isao, Sonamoto, Rie, Knapp, Stefan, Papadopoulos, Chrisovalantis, Becker, Walter
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526990/
https://ncbi.nlm.nih.gov/pubmed/28743892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06874-w
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