Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Altered proteolysis of the beta-amyloid precursor protein (beta APP) resulting in release of the approximately 40-residue amyloid beta-protein (A beta P) may be a seminal pathogenetic event in Alzheimer disease. Using region-specific beta APP antibodies, we searched for stable proteolytic intermedia...

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Bibliographic Details
Main Authors: Tamaoka, A, Kalaria, R N, Lieberburg, I, Selkoe, D J
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC48446/
https://ncbi.nlm.nih.gov/pubmed/1531538
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