p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases.
The protein product of the neu protooncogene, p185c-neu, is structurally similar to the epidermal growth factor receptor (EGFR). Overexpression of these two receptor tyrosine kinases, but not either separately, leads to transformation and tumorigenicity. Heterodimerization of p185c-neu and EGFR occu...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48443/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1346931/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.4.1330 |
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