Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4

Facioscapulohumeral muscular dystrophy is caused by incomplete epigenetic repression of the transcription factor DUX4 in skeletal muscle. A copy of DUX4 is located within each unit of the D4Z4 macrosatellite repeat array and its derepression in somatic cells is caused by either repeat array contract...

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Détails bibliographiques
Publié dans:Epigenetics
Auteurs principaux: Balog, Judit, Thijssen, Peter E., Shadle, Sean, Straasheijm, Kirsten R., van der Vliet, Patrick J., Krom, Yvonne D., van den Boogaard, Marlinde L., de Jong, Annika, F Lemmers, Richard J. L., Tawil, Rabi, Tapscott, Stephen J., van der Maarel, Silvère M.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844215/
https://ncbi.nlm.nih.gov/pubmed/26575099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1113798
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