Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells

Oxidation of 5-methylcytosine by TET family proteins can induce DNA replication-dependent (passive) DNA demethylation and base excision repair (BER)-based (active) DNA demethylation. The balance of active vs. passive TET-induced demethylation remains incompletely determined. In the context of large...

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Bibliographic Details
Published in:Epigenetics
Main Authors: Jin, Chunlei, Qin, Taichun, Barton, Michelle Craig, Jelinek, Jaroslav, Issa, Jean-Pierre J
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844212/
https://ncbi.nlm.nih.gov/pubmed/26440216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2015.1091145
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