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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair
BACKGROUND: DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation. This is accompanied by major chromatin remodelling and generates a marked asym...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4037648/ https://ncbi.nlm.nih.gov/pubmed/24279473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-39 |
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