Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure

Folliculin (FLCN) is an autosomal dominant tumor suppressor gene that modulates diverse signaling pathways required for growth, proliferation, metabolism, survival, motility and adhesion. FLCN is an essential protein required for murine embryonic development, embryonic stem cell (ESC) commitment, an...

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Pubblicato in:Stem Cells
Autori principali: Baba, Masaya, Toyama, Hirofumi, Sun, Lei, Takubo, Keiyo, Suh, Hyung-Chan, Hasumi, Hisashi, Nakamura-Ishizu, Ayako, Hasumi, Yukiko, Klarmann, Kimberly D., Nakagata, Naomi, Schmidt, Laura S., Linehan, W. Marston, Suda, Toshio, Keller, Jonathan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843833/
https://ncbi.nlm.nih.gov/pubmed/27095138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2293
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