Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure

Folliculin (FLCN) is an autosomal dominant tumor suppressor gene that modulates diverse signaling pathways required for growth, proliferation, metabolism, survival, motility and adhesion. FLCN is an essential protein required for murine embryonic development, embryonic stem cell (ESC) commitment, an...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Baba, Masaya, Toyama, Hirofumi, Sun, Lei, Takubo, Keiyo, Suh, Hyung-Chan, Hasumi, Hisashi, Nakamura-Ishizu, Ayako, Hasumi, Yukiko, Klarmann, Kimberly D., Nakagata, Naomi, Schmidt, Laura S., Linehan, W. Marston, Suda, Toshio, Keller, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843833/
https://ncbi.nlm.nih.gov/pubmed/27095138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2293
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