Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure

Folliculin (FLCN) is an autosomal dominant tumor suppressor gene that modulates diverse signaling pathways required for growth, proliferation, metabolism, survival, motility and adhesion. FLCN is an essential protein required for murine embryonic development, embryonic stem cell (ESC) commitment, an...

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Bibliografski detalji
Izdano u:Stem Cells
Glavni autori: Baba, Masaya, Toyama, Hirofumi, Sun, Lei, Takubo, Keiyo, Suh, Hyung-Chan, Hasumi, Hisashi, Nakamura-Ishizu, Ayako, Hasumi, Yukiko, Klarmann, Kimberly D., Nakagata, Naomi, Schmidt, Laura S., Linehan, W. Marston, Suda, Toshio, Keller, Jonathan R.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843833/
https://ncbi.nlm.nih.gov/pubmed/27095138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2293
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