Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation

There are many opportunities to use macromolecules, such as peptides and oligonucleotides, for intracellular applications. Despite this, general methods for delivering these molecules to the cytosol in a safe and efficient manner are not available. Efforts to develop a variety of intracellular drug...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M., DeGrado, William F.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843813/
https://ncbi.nlm.nih.gov/pubmed/25630033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500759p
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