Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in murine GBM models and that circulating Ang-2 levels in GBM patients rebound afte...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843449/
https://ncbi.nlm.nih.gov/pubmed/27044097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525349113
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