Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in murine GBM models and that circulating Ang-2 levels in GBM patients rebound afte...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843449/
https://ncbi.nlm.nih.gov/pubmed/27044097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525349113
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