Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in murine GBM models and that circulating Ang-2 levels in GBM patients rebound afte...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843449/
https://ncbi.nlm.nih.gov/pubmed/27044097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525349113
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