Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits of anti-VEGF receptor (VEGFR) treatment in murine GBM models and that circulating Ang-2 levels in GBM patients rebound afte...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2016
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843449/
https://ncbi.nlm.nih.gov/pubmed/27044097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525349113
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