Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

BACKGROUND: Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. METHODS: Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5–10 per group) were treated with an anti-MMP14 inhibitory antibod...

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Detalhes bibliográficos
Publicado no:J Natl Cancer Inst
Main Authors: Ager, Eleanor I., Kozin, Sergey V., Kirkpatrick, Nathaniel D., Seano, Giorgio, Kodack, David P., Askoxylakis, Vasileios, Huang, Yuhui, Goel, Shom, Snuderl, Matija, Muzikansky, Alona, Finkelstein, Dianne M., Dransfield, Daniel T., Devy, Laetitia, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402365/
https://ncbi.nlm.nih.gov/pubmed/25710962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv017
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