Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases

Brain metastases are a serious obstacle in the treatment of patients with human epidermal growth factor receptor-2 (HER2)–amplified breast cancer. Although extracranial disease is controlled with HER2 inhibitors in the majority of patients, brain metastases often develop. Because these brain metasta...

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Main Authors: Kodack, David P., Chung, Euiheon, Yamashita, Hiroshi, Incio, Joao, Duyverman, Annique M. M. J., Song, Youngchul, Farrar, Christian T., Huang, Yuhui, Ager, Eleanor, Kamoun, Walid, Goel, Shom, Snuderl, Matija, Lussiez, Alisha, Hiddingh, Lotte, Mahmood, Sidra, Tannous, Bakhos A., Eichler, April F., Fukumura, Dai, Engelman, Jeffrey A., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494882/
https://ncbi.nlm.nih.gov/pubmed/23071298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216078109
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