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Identification of residues crucial for the interaction between human neuroglobin and the α-subunit of heterotrimeric G(i) protein

Mammalian neuroglobin (Ngb) protects neuronal cells under conditions of oxidative stress. We previously showed that human Ngb acts as a guanine nucleotide dissociation inhibitor (GDI) for the α-subunits of heterotrimeric G(i/o) proteins and inhibits the decrease in cAMP concentration, leading to pro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Takahashi, Nozomu, Wakasugi, Keisuke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842972/
https://ncbi.nlm.nih.gov/pubmed/27109834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24948
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