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Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping
Mammalian genes do not transcribe RNA continuously but in bursts. Transcriptional output can be modulated by altering burst fraction or burst size, but how regulatory elements control bursting parameters remains unclear. Single-molecule RNA FISH experiments revealed that the β-globin enhancer (LCR)...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4842148/ https://ncbi.nlm.nih.gov/pubmed/27067601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.007 |
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