Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

PURPOSE: The current study presents [(18)F]PARPi as imaging agent for PARP1 expression. PROCEDURES: [(18)F]PARPi was generated by conjugating a 2H-phthalazin-1-one scaffold to 4-[(18)F]fluorobenzoic acid. Biochemical assays, optical in vivo competition, biodistribution analysis, positron emission to...

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Publicat a:Mol Imaging Biol
Autors principals: Carney, Brandon, Carlucci, Giuseppe, Salinas, Beatriz, Di Gialleonardo, Valentina, Kossatz, Susanne, Vansteene, Axel, Longo, Valerie A., Bolaender, Alexander, Chiosis, Gabriela, Keshari, Kayvan R., Weber, Wolfgang A., Reiner, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841747/
https://ncbi.nlm.nih.gov/pubmed/26493053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-015-0904-y
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