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Exploration of the conserved A+C wobble pair within the ribosomal peptidyl transferase center using affinity purified mutant ribosomes

Protein synthesis in the ribosome's large subunit occurs within an active site comprised exclusively of RNA. Mutational studies of rRNA active site residues could provide valuable insight into the mechanism of peptide bond formation, but many of these mutations cause a dominant lethal phenotype...

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Bibliografski detalji
Glavni autori: Hesslein, Ashley Eversole, Katunin, Vladimir I., Beringer, Malte, Kosek, Anne B., Rodnina, Marina V., Strobel, Scott A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC484164/
https://ncbi.nlm.nih.gov/pubmed/15256541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh672
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