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Stochastic epigenetic outliers can define field defects in cancer
BACKGROUND: There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent stochastic “outlier” events. This presents a statistical challenge for standard fe...
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| Publié dans: | BMC Bioinformatics |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840974/ https://ncbi.nlm.nih.gov/pubmed/27103033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1056-z |
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