Stochastic epigenetic outliers can define field defects in cancer

BACKGROUND: There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent stochastic “outlier” events. This presents a statistical challenge for standard fe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Bioinformatics
Main Authors: Teschendorff, Andrew E., Jones, Allison, Widschwendter, Martin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840974/
https://ncbi.nlm.nih.gov/pubmed/27103033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1056-z
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