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DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding cancer aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast tissue samples, including 50 from cancer-free women and 84 from matched normal cancer pairs. We use...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Teschendorff, Andrew E, Gao, Yang, Jones, Allison, Ruebner, Matthias, Beckmann, Matthias W., Wachter, David L., Fasching, Peter A., Widschwendter, Martin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4740178/
https://ncbi.nlm.nih.gov/pubmed/26823093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10478
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