Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53 null mouse model of prostate cancer, we show that two classes of luminal progenitors exist within a tumor. N...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Agarwal, Supreet, Hynes, Paul G., Tillman, Heather S., Lake, Ross, Abou-Kheir, Wassim G., Fang, Lei, Casey, Orla M., Ameri, Amir H., Martin, Philip L., Yin, Juan Juan, Iaquinta, Phillip J., Karthaus, Wouter R., Clevers, Hans C., Sawyers, Charles L., Kelly, Kathleen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840850/
https://ncbi.nlm.nih.gov/pubmed/26628377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.077
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