TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neuro...

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Published in:Brain
Main Authors: Nam, Jin H., Park, Eun S., Won, So-Yoon, Lee, Yu A., Kim, Kyoung I., Jeong, Jae Y., Baek, Jeong Y., Cho, Eun J., Jin, Minyoung, Chung, Young C., Lee, Byoung D., Kim, Sung Hyun, Kim, Eung-Gook, Byun, Kyunghee, Lee, Bonghee, Woo, Dong Ho, Lee, C. Justin, Kim, Sang R., Bok, Eugene, Kim, Yoon-Seong, Ahn, Tae-Beom, Ko, Hyuk Wan, Brahmachari, Saurav, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M., Jin, Byung K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840550/
https://ncbi.nlm.nih.gov/pubmed/26490328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv297
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