TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neuro...

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Veröffentlicht in:Brain
Hauptverfasser: Nam, Jin H., Park, Eun S., Won, So-Yoon, Lee, Yu A., Kim, Kyoung I., Jeong, Jae Y., Baek, Jeong Y., Cho, Eun J., Jin, Minyoung, Chung, Young C., Lee, Byoung D., Kim, Sung Hyun, Kim, Eung-Gook, Byun, Kyunghee, Lee, Bonghee, Woo, Dong Ho, Lee, C. Justin, Kim, Sang R., Bok, Eugene, Kim, Yoon-Seong, Ahn, Tae-Beom, Ko, Hyuk Wan, Brahmachari, Saurav, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M., Jin, Byung K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840550/
https://ncbi.nlm.nih.gov/pubmed/26490328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv297
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