TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neuro...

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Publicado no:Brain
Main Authors: Nam, Jin H., Park, Eun S., Won, So-Yoon, Lee, Yu A., Kim, Kyoung I., Jeong, Jae Y., Baek, Jeong Y., Cho, Eun J., Jin, Minyoung, Chung, Young C., Lee, Byoung D., Kim, Sung Hyun, Kim, Eung-Gook, Byun, Kyunghee, Lee, Bonghee, Woo, Dong Ho, Lee, C. Justin, Kim, Sang R., Bok, Eugene, Kim, Yoon-Seong, Ahn, Tae-Beom, Ko, Hyuk Wan, Brahmachari, Saurav, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M., Jin, Byung K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840550/
https://ncbi.nlm.nih.gov/pubmed/26490328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv297
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