TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF

Currently there is no neuroprotective or neurorestorative therapy for Parkinson’s disease. Here we report that transient receptor potential vanilloid 1 (TRPV1) on astrocytes mediates endogenous production of ciliary neurotrophic factor (CNTF), which prevents the active degeneration of dopamine neuro...

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Publicat a:Brain
Autors principals: Nam, Jin H., Park, Eun S., Won, So-Yoon, Lee, Yu A., Kim, Kyoung I., Jeong, Jae Y., Baek, Jeong Y., Cho, Eun J., Jin, Minyoung, Chung, Young C., Lee, Byoung D., Kim, Sung Hyun, Kim, Eung-Gook, Byun, Kyunghee, Lee, Bonghee, Woo, Dong Ho, Lee, C. Justin, Kim, Sang R., Bok, Eugene, Kim, Yoon-Seong, Ahn, Tae-Beom, Ko, Hyuk Wan, Brahmachari, Saurav, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M., Jin, Byung K.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840550/
https://ncbi.nlm.nih.gov/pubmed/26490328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv297
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