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Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
The mechanism of Bax/Bak activation remains a central question in mitochondria-dependent apoptotic signaling. While it is established that all proapoptotic Bcl-2 homology 3 (BH3)-only proteins bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutralization leads to Bax/Bak acti...
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| Publicado no: | Genes Dev |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840302/ https://ncbi.nlm.nih.gov/pubmed/27056669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276725.115 |
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