Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas()()

Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to c...

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Veröffentlicht in:Neoplasia
Hauptverfasser: Myers, Meagan B., Banda, Malathi, McKim, Karen L., Wang, Yiying, Powell, Michael J., Parsons, Barbara L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2016
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840288/
https://ncbi.nlm.nih.gov/pubmed/27108388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.03.002
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