Enhancing the evaluation of PI3K inhibitors through 3D melanoma models

Targeted therapies for mutant BRAF metastatic melanoma are effective but not curative due to acquisition of resistance. PI3K signaling is a common mediator of therapy resistance in melanoma; thus, the need for effective PI3K inhibitors is critical. However, testing PI3K inhibitors in adherent cultur...

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Publicat a:Pigment Cell Melanoma Res
Autors principals: Shannan, Batool, Chen, Quan, Watters, Andrea, Perego, Michela, Krepler, Clemens, Thombre, Rakhee, Li, Ling, Rajan, Geena, Peterson, Scott, Gimotty, Phyllis A., Wilson, Melissa, Nathanson, Katherine L., Gangadhar, Tara C., Schuchter, Lynn M., Weeraratna, Ashani T., Herlyn, Meenhard, Vultur, Adina
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840066/
https://ncbi.nlm.nih.gov/pubmed/26850518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12465
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